Here is an article that helps to connect our grid-computing project on HIV/AIDS with our Evolution class.
Enjoy!
HIV Evolution and Escape
by D. D. Richmond, S. J. Little , D. M. Smith, T. Wrin, C. Petropoulos, and J. K. Wong (2004)
Transactions of the American Clinical and Climatological Association, Vol. 115
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2263778/pdf/tacca00001-0343.pdf
Hi all,
ReplyDeleteFor some reason, that link works when I copy and paste it but not when I click on it. Puzzling. Anyway, below are the questions concerning your paper. My advice is for you to try to divide them up roughly evenly among your group members. You are even welcome to post the answers independently if you'd like; just be sure to reiterate the question.
1. State each of Darwin’s four postulates. Fully explain how each of the three themes in this article (antiretroviral therapy, different anatomical compartments, and neutralizing antibody) meets each of the four postulates for evolution of HIV by natural selection.
2. What happens to HIV populations in the absence of pharmaceutical (environmental) pressure? Why?
3. Examine Figure 5. What does it tell us about the strains in the spleen (lymph) compared to those in the central nervous system (brain and CSF)? Why use a phylogenetic tree to give us information about anatomic compartmentalization of HIV populations?
4. Why would HIV populations in distinct anatomical areas evolve differently?
Bonus: What does perspicacious (p.289) mean? Do you think it's an accurate adjective to describe Darwin, and why?